A thermosensitive hydroxybutyl chitosan hydrogel as a potential co-delivery matrix for drugs on keloid inhibition

作者：Bao, Zixian; Gao, Ping; Xia, Guixue; Wang, Zhiguo; Kong, Ming; Feng, Chao; Cheng, Xiaojie^*; Liu, Ya^*; Chen, Xiguang^*

来源：Journal of Materials Chemistry B, 2016, 4(22): 3936-3944.

DOI：10.1039/c6tb00378h

• HYPERTROPHIC SCARS
• 5-FLUOROURACIL
• MANAGEMENT
• RELEASE
• CULTURE
• DOXORUBICIN
• EXPRESSION
• PREVENTION
• SYSTEM
• GROWTH

Keloid is a kind of unique human fibroproliferative dermal disease, and there are still no optimal treatment methods for it. In the present study, a thermosensitive hydroxybutyl chitosan (HBC) hydrogel as a co-delivery matrix for 5-fluorouracil (5-FU) and dexamethasone sodium phosphate (DEXSP) in keloid treatment was developed. The gelation temperature of the HBC hydrogel was observed to be 25.7 degrees C by rheology analysis. The HBC hydrogel showed sustained drug release capacity (5-FU, 89.3 +/- 3.4%; DEXSP, 95.6 +/- 3.9%) for drug delivery. The HBC hydrogel was shown to be cytocompatible, while the dual drug-loaded HBC hydrogel could suppress the proliferation of keloid fibroblasts (KFs). The keloid biopsies treated with the dual drug-loaded hydrogel could be inhibited through the efficient suppression of VEGF expression within 7 days. The results suggested that the HBC hydrogel could be applied as a potential co-delivery matrix for drugs in the keloid therapy field.

• 出版日期2016
• 单位中国海洋大学; 青岛大学