Detection of vapor-phase organophosphate threats using wearable conformable integrated epidermal and textile wireless biosensor systems

作者：Mishra Rupesh K; Martin Aida; Nakagawa Tatsuo; Barfidokht Abbas; Lu Xialong; Sempionatto Juliane R; Lyu Kay Mengjia; Karajic Aleksandar; Musameh Mustafa M; Kyratzis Ilias L; Wang Joseph

来源：Biosensors and Bioelectronics, 2018, 101: 227-234.

DOI：10.1016/j.bios.2017.10.044

• Wearable sensor
• Integrated flexible electronics
• Organophosphate
• Nerve agent
• Vapor phase detection
• OPH-biosensor

Flexible epidermal tattoo and textile-based electrochemical biosensors have been developed for vapor-phase detection of organophosphorus (OP) nerve agents. These new wearable sensors, based on stretchable organophosphorus hydrolase (OPH) enzyme electrodes, are coupled with a fully integrated conformal flexible electronic interface that offers rapid and selective square-wave voltammetric detection of OP vapor threats and wireless data transmission to a mobile device. The epidermal tattoo and textile sensors display a good reproducibility (with RSD of 2.5% and 4.2%, respectively), along with good discrimination against potential interferences and linearity over the 90-300 mg/L range, with a sensitivity of 10.7 mu A.cm(3).mg(-1) (R-2 = 0.983) and detection limit of 12 mg/L in terms of OP air density. Stress-enduring inks, used for printing the electrode transducers, ensure resilience against mechanical deformations associated with textile and skin-based on-body sensing operations. Theoretical simulations are used to estimate the OP air density over the sensor surface. These fully integrated wearable wireless tattoo and textile-based nerve-agent vapor biosensor systems offer considerable promise for rapid warning regarding personal exposure to OP nerve-agent vapors in variety of decentralized security applications.

• 出版日期2018-3-15