Multistimuli Responsive Supramolecular Polymeric Nanoparticles Formed by Calixpyridinium and Chondroitin 4-Sulfate

作者：Wang, Kui^*; Ren, Xiao-Wei; Cui, Jian-Hua; Guo, Jia-Shuang; Xing, Si-Yang^*; Dou, Hong-Xi; Wang, Meng-Meng

来源：ChemistrySelect, 2018, 3(10): 2789-2794.

DOI：10.1002/slct.201800570

• aggregation
• calixpyridinium
• host-guest systems
• multistimuli responsive
• nanoparticles

We have successfully constructed multistimuli responsive supramolecular polymeric nanoparticles based on the complexation of calixpyridinium with polyanionic chondroitin 4-sulfate. The nanoparticles are disassembled upon increasing pH from 6 to 9, while a pH-responsive morphological conversion from spherical nanoparticles to nanorods is observed upon decreasing pH from 6 to 2. Adding a competitive guest can also disrupt the assembly, representing the host-guest inclusion response. Interestingly, an unexpected hyaluronidase-responsive morphological conversion from spherical nanoparticles to wire-like suprastructures rather than disassembly is also observed, as a result of the hyaluronidase-induced cleavage of chondroitin 4-sulfate. The multistimuli responsive morphological conversion property with various dimensions, along with the facile preparation, will make this supramolecular polymeric assembly approach well-suitable for a variety of important material applications.

• 出版日期2018-3-14
• 单位天津师范大学