New alkaloids and diterpenes from a deep ocean sediment derived fungus Penicillium sp.

作者：Du Lin; Li Dehai; Zhu Tianjiao; Cai Shengxin; Wang Fengping; Xiao Xiang; Gu Qianqun^*

来源：Tetrahedron, 2009, 65(5): 1033-1039.

DOI：10.1016/j.tet.2008.11.078

• Penicillium sp.
• Alkaloid
• Diterpene
• Deep ocean
• Fungus

Four new alkaloids. including two new meleagrin analogs, meleagrins B (2) and C (3), and two new diketopiperazines, roquefortines F (5) and G (6), together with six new diterpenes, conidiogenones B-G (7-12), were isolated from a deep ocean sediment derived fungus Penicillium sp. The structures and stereochemistry of the new compounds were elucidated by spectroscopic methods. The cytotoxicity of the new compounds against the HL-60, A-549, BEL-7402, and MOLT-4 cell lines was evaluated.

• 出版日期2009-1-31
• 单位中国海洋大学; 国家海洋局第三海洋研究所