科研之友
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摘要
Chemically stable hydrophobic magnetic nanoparticles were prepared by using an isocyanate as an anchoring group and were applied to the soluble tag-assisted liquid-phase peptide synthesis of the peptide elastin. Couplings and deprotections were effectively performed in the presence of the nanoparticles, and the desired product was rapidly collected as a "magnetic" precipitate, enabling a one-pot procedure. Sonication of the nanoparticles significantly suppressed gelation of the reaction mixture, which allowed the highly aggregating elastin peptide to be synthesized in one pot without difficulty.
- 出版日期2017-11-2
