A hypervariable STR polymorphism in the CFI gene: Mutation rate and no linkage disequilibrium with FGA

作者：Yuasa Isao^*; Nakayashiki Nori; Umetsu Kazuo; Nishimukai Hiroaki; Matsusue Aya; Dewa Koji

来源：Legal Medicine, 2013, 15(3): 161-163.

DOI：10.1016/j.legalmed.2012.10.005

• Complement factor I
• Linkage
• Mutation rate
• Short tandem repeat (STR)
• Variant allele

A hypervariable short tandem repeat (STR) polymorphism in intron 7 of the human complement factor I gene (CFI) was investigated to estimate the mutation rate in Japanese samples and to test linkage disequilibrium (LD) with an STR in the fibrinogen alpha chain gene (FGA). The expected heterozygosity and the mutation rate of CFI were estimated Lobe 0.917 and 0.002, respectively. No LD was observed between CFI and FGA. CFI is a useful supplementary marker for forensic science.

• 出版日期2013-5