Mukaiyama's reagent promoted C-N bond formation: a new method to synthesize 3-alkylquinazolin-4-ones

作者：Punthasee Puminun; Vanitcha Avassaya; Wacharasindhu Sumrit^*

来源：Tetrahedron Letters, 2010, 51(13): 1713-1716.

DOI：10.1016/j.tetlet.2010.01.087

A new approach to synthesize 3-alkylquinazolin-4-ones is developed. Treatment of quinazolin-4-ones with Mukaiyama's reagent, a base and a primary amine nucleophile results in the formation of 3-alkylquinazolin-4-ones in moderate to good yields under mild conditions. Using this methodology, a one-step synthesis of the natural alkaloid, echinozolinone, is accomplished.

• 出版日期2010-3-31