A Sequential One-Pot Protocol for the Synthesis of Dihydrobenzo[6,7]indolo[3 ',4 ':3,4,5]azepino[2,1-a]isoquinolines Using a Gold-Silver Combined Catalyst

Saifuddin Mohammad; Samala Srinivas; Krishna Deevi G Venkata; Kundu Bijoy<sup>*</sup>

doi:10.1055/s-0033-1338424

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A Sequential One-Pot Protocol for the Synthesis of Dihydrobenzo[6,7]indolo[3 ',4 ':3,4,5]azepino[2,1-a]isoquinolines Using a Gold-Silver Combined Catalyst

作者：Saifuddin Mohammad; Samala Srinivas; Krishna Deevi G Venkata; Kundu Bijoy^*

来源：Synthesis, 2013, 45(11): 1553-1563.

DOI：10.1055/s-0033-1338424

摘要

A sequential one-pot protocol for the synthesis of indole-based peri-annulated polyheterocycles using trifluoroacetic acid and a gold-silver combined catalyst system is described. The reaction is thought to proceed via an imine formation-cationic pi-cyclization-alkyne activation-intramolecular hydroamination sequence to yield novel dihydrobenzo[6,7]indolo[3',4':3,4,5]azepino[2,1-a]isoquinolines in good yields.