Age-dependent changes in recovery sleep after 48 hours of sleep deprivation in rats

作者：Mendelson WB^*; Bergmann BM

来源：Neurobiology of Aging, 2000, 21(5): 689-693.

DOI：10.1016/S0197-4580(00)00154-8

• sleep deprivation
• disk-over-water method
• sleep
• REM sleep
• homeostatic regulation

To characterize possible changes in homeostatic regulation of sleep with aging, we have examined sleep stages during recovery sleep after 48 h of sleep deprivation in young (3 months), middle aged (12 months), and old (24 months) rats. It was found that young and middle aged, in contrast to old rats, had large (21-24%) increases in total sleep time during recovery sleep; the old rats experienced a quantitatively small (8%) but significant rise in total sleep. NREM sleep increased significantly during the recovery period in young and middle aged, but not older rats. High voltage NREM sleep (HS2) declined by 30% during recovery in the young animals, but remained unchanged compared to baseline in the middle aged and old animals. The young and middle aged rats had increases in REM sleep during recovery compared to their baseline by 96% and 93%, respectively, which was significantly greater than a 65% increase during recovery in the old rats. Increases in total sleep and REM sleep during recovery were largely confined to the first 6 h in young and middle aged rats, but maxima for the old rats occurred in the second 6 h.

• 出版日期2000-10