Molecular Pathogenesis of Myeloproliferative Neoplasms: Influence of Age and Gender

作者：Patterson Fortin Jeffrey; Moliterno Alison R^*

来源：Current Hematologic Malignancy Reports, 2017, 12(5): 424-431.

DOI：10.1007/s11899-017-0411-0

• JAK2
• Myeloproliferative neoplasms
• Pathogenesis
• Sex differences
• Aging

The myeloproliferative neoplasms polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF) display distinct clinical and pathologic features but are characterized by mutations in JAK2, MPL, and CALR leading to activation of the JAK-STAT pathway. This review addresses the pathogenesis and mechanisms of these mutant alleles and the unique interactions of both of age and gender.

• 出版日期2017-10