Pesticide concentrations in maternal and umbilical cord sera and their relation to birth outcomes in a population of pregnant women and newborns in New Jersey

作者：Barr Dana Boyd; Ananth Cande V; Yan Xiaoyong; Lashley Susan; Smulian John C; Ledoux Thomas A; Hore Paromita; Robson Mark G^*

来源：Science of the Total Environment, 2010, 408(4): 790-795.

DOI：10.1016/j.scitotenv.2009.10.007

• Pesticides
• Chlorpyrifos
• Cord blood
• Maternal blood
• Pregnant women
• New Jersey
• Birth outcome
• Birth weight

We evaluated in utero exposures to pesticides by measuring maternal and cord serum biomarkers in a New Jersey cohort of pregnant women and the birth outcomes of their neonates. The study was based on 150 women that underwent an elective cesarean delivery at term in a hospital in central New Jersey. We evaluated the following pesticide compounds in both maternal and umbilical cord sera: chlorpyrifos, diazinon, carbofuran, chlorothalonil, dacthal, metolachlor, trifluralin and diethyl-m-toluamide (DEET). Of these compounds, chlorpyrifos, carbofuran, chlorothalonil, trifluralin, metolachlor and DEET were the pesticides most frequently detected in the serum samples. We found high (>= 75th percentile) metolachlor concentrations in cord blood that were related to birth weight (3605 g in upper quartile vs 3399 g; p = 0.05). We also observed an increase in abdominal circumference with increasing cord dichloran concentrations (p = 0.031). These observations suggest that in utero exposures to certain pesticides may alter birth outcomes.

• 出版日期2010-1-15