科研之友
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摘要
Polychlorinated biphenyls (PCB) cause reproductive failure in mink. Ovulation and nidation occur, but the fetuses die during gestation. The toxicity of different chlorinated biphenyl (CB) congeners differs markedly. Dioxin-like congeners with no (O-ortho CBs) chlorine in the ortho position to the biphenyl bond are considered to be highly toxic. Altogether, 13 groups of 10 female mink (Mustelu vison) were exposed to PCB or CB fractions thereof during the reproductive season of 1988 and 1989. In 1988, one group of mink received 2 mg/day of Clophen A50 and five groups received single fractions thereof or synthetic O-ortho CB in their diet. In 1989, one group received 1.64 mg/day of Aroclor 1254 and six groups received combinations of fractions thereof. The daily amounts of the fractions administered per animal were equivalent to those present in 2 mg of Clophen A50 or 1.64 mg of Aroclor 1254. After administration for 3 months in both experiments, the animals were killed 5 days after parturition. Histological examination focused on the placental sites. The most involuted placental sites were those of early fetal death in primiparous, non-whelping animals in the 1989 experiment. The least involuted placental sites, displaying a hyperplastic and pleomorphic uterine luminal epithelium, in which proliferating cell nuclear antigen (PCNA) was present, were those of late fetal death in biparous, non-whelping animals in the 1988 experiment. The survival of the fetoplacental unit was related to PCB exposure. The histology of the placental sites seemed only to be related to the survival time of the fetuses and to the number of former reproductive seasons.
- 出版日期1995-12
