A Theory of Germinal Center B Cell Selection, Division, and Exit

作者：Meyer Hermann Michael^*; Mohr Elodie; Pelletier Nadege; Zhang Yang; Victora Gabriel D; Toellner Kai Michael

来源：Cell Reports, 2012, 2(1): 162-174.

DOI：10.1016/j.celrep.2012.05.010

High-affinity antibodies are generated in germinal centers in a process involving mutation and selection of B cells. Information processing in germinal center reactions has been investigated in a number of recent experiments. These have revealed cell migration patterns, asymmetric cell divisions, and cell-cell interaction characteristics, used here to develop a theory of germinal center B cell selection, division, and exit (the LEDA model). According to this model, B cells selected by T follicular helper cells on the basis of successful antigen processing always return to the dark zone for asymmetric division, and acquired antigen is inherited by one daughter cell only. Antigen-retaining B cells differentiate to plasma cells and leave the germinal center through the dark zone. This theory has implications for the functioning of germinal centers because compared to previous models, high-affinity antibodies appear one day earlier and the amount of derived plasma cells is considerably larger.

• 出版日期2012-7