A Catalyst-Free Synthesis of Phosphinic Amides Using O-Benzoylhydroxylamines

作者:Zhu Rui; Pan Chongqing; Gu Zhenhua
来源:Organic Letters, 2015, 17(23): 5862-5865.
DOI:10.1021/acs.orglett.5b03056

摘要

A practical approach for the synthesis of phosphinic amides via the coupling of secondary phosphine oxides (SPOs) with O-benzoylhydroxylamines has been reported. Simply heating the mixture of SPOs and O-benzoylhydroxylamines in the presence of K2CO3 gave the phosphinic amides in moderate to excellent yields under an open air system. This method provides a practical and catalyst-free method for the synthesis of various synthetically valuable phosphinic amides.