Arg-Thz is a minimal substrate for the N-alpha,N-alpha-arginyl methyltransferase involved in the biosynthesis of plantazolicin

作者：Piwowarska Natalia A; B****a Srinivas; Overkleeft Hermen S; Suessmuth Roderich D

来源：Chemical communications, 2013, 49(91): 10703-10705.

DOI：10.1039/c3cc45898a

The final biosynthetic step towards plantazolicin (PZN) comprises N-alpha,N-alpha-arginyl methyltransferase (PznL) mediated N-terminal bis-methylation. We show that PznL processes truncated desmethyl-plantazolicin analogues, but only those with an N-terminal guanidine side chain derived from arginine. PznL specificity, which is narrow, depends on the side chain of the N-terminal amino acid linked to an azole, and not so much on the number of azoles.

• 出版日期2013