Acute and chronic suppression of the central ghrelin signaling system reveals a role in food anticipatory activity

作者：Verhagen Linda A W; Egecioglu Emil; Luijendijk Mieneke C M; Hillebrand Jacquelien J G; Adan Roger A H^*; Dickson Suzanne L

来源：European Neuropsychopharmacology, 2011, 21(5): 384-392.

DOI：10.1016/j.euroneuro.2010.06.005

• Ghrelin
• GHS-R1A antagonist
• Activity-based anorexia
• Food anticipatory activity
• Running wheel activity
• JMV2959

Using the rodent activity-based anorexia (ABA) model that mimics clinical features of anorexia nervosa that include food restriction-induced hyperlocomotion, we found that plasma ghrelin levels are highly associated with food anticipatory behaviour, measured by running wheel activity in rats. Furthermore, we showed that ghrelin receptor (GUS-R1A) knockout mice do not anticipate food when exposed to the ABA model, unlike their wild type littermate controls. Likewise, food anticipatory activity in the ABA model was suppressed by a GHS-R1A antagonist administered either by acute central (ICV) injection to rats or by chronic peripheral treatment to mice. Interestingly, the GHS-R1A antagonist did not alter food intake in any of these models. Therefore, we hypothesize that suppression of the central ghrelin signaling system via GHS-R1A provides an interesting therapeutic target to treat hyperactivity in patients suffering from anorexia nervosa.

• 出版日期2011-5