A general method for regioselective Heck arylation of electron-rich N-acyl-N-vinylamine with aryl halides

作者：Liu, Zhihua; Xu, Dan; Tang, Weijun; Xu, Lijin^*; Mo, Jun; Xiao, Jianliang

来源：Tetrahedron Letters, 2008, 49(17): 2756-2760.

DOI：10.1016/j.tetlet.2008.02.144

• IONIC LIQUIDS
• ENANTIOSELECTIVE HYDROGENATION
• PALLADIUM CATALYSIS
• ENAMIDES
• COMPLEXES
• MECHANISM
• OLEFINS
• LIGAND
• REGIOCHEMISTRY
• ALCOHOLS

A highly efficient protocol for the Pd-catalyzed regioselective Heck arylation of the electron-rich olefin N-acyl-N-vinylamine with aryl halides has been developed. In the presence of hydrogen-bond donor [H2NiPr2][BF4] as an additive, this proceeds smoothly in isopropanol to afford exclusively the branched products in high yields.

• 出版日期2008-4-21
• 单位中国人民大学