Antioxidant and Anti-Inflammatory Properties of Anacardium occidentale Leaf Extract

作者：Souza Natalia Cabral^*; de Oliveira Juliana Medeiros; Morrone Maurilio da Silva; Albanus Ricardo D'Oliveira; Medeiros Amarante Maria do Socorro; Camillo Christina da Silva; Zucolotto Langassner Silvana Maria; Gelain Daniel Pens; Fonseca Moreira Jose Claudio; Siqueira Dalmolin Rodrigo Juliani; de Bittencourt Pasquali Matheus Augusto

来源：Evidence-Based Complementary and Alternative Medicine, 2017, 2017: 2787308.

DOI：10.1155/2017/2787308

In tropical America, principally inNortheastern Brazil, the leaf extract of Anacardium occidentale is traditionally used for treatment of different diseases. However, chemical and biological properties and activities of Anacardium occidentale are poorly investigated and known. Here, we evaluated the antioxidant and anti-inflammatory activities "in vitro" of leaf extract from Anacardium occidentale. Our results show that leaf extract exhibits antioxidant activity when used to treat RAW 264.7 macrophage cells. Antioxidant effects were observed by decrease in oxidative damage in macrophage cells treated with 0.5 mu g/mL and 5 mu g/mL of leaf extract. Moreover, leaf extract reversed oxidative damage and inflammatory parameters induced in LPS-stimulated RAW264.7 macrophage cells. Leaf extract at 0.5 mu g/mL and 5 mu g/mL was able to inhibit release of TNF-alpha and IL-1 beta in LPS-stimulated cells. Taken together, our results indicate antioxidant and anti-inflammatory effects of leaf extract from Anacardium occidentale and reveal the positive effects that intake of these products can mediate in biological system.

• 出版日期2017