Antiplasmodial and antimalarial activities of quinolone derivatives: An overview

作者:Fan, Yi-Lei; Cheng, Xiang-Wei; Wu, Jian-Bing; Liu, Min; Zhang, Feng-Zhi*; Xu, Zhi; Feng, Lian-Shun
来源:European Journal of Medicinal Chemistry, 2018, 146: 1-14.
DOI:10.1016/j.ejmech.2018.01.039

摘要

Malaria remains one of the most deadly infectious diseases globally. Considering the growing spread of resistance, development of new and effective antimalarials remains an urgent priority. Quinolones, which are emerged as one of the most important class of antibiotics in the treatment of various bacterial infections, showed potential in vitro antiplasmodial and in vivo antimalarial activities, making them promising candidates for the chemoprophylaxis and treatment of malaria. This review presents the current progresses and applications of quinolone-based derivatives as potential antimalarials to pave the way for the development of new antimalarials.