Antiinflammatory and analgesic effect of herbal cocktail Hongbaekjeong via inhibition of proinflammatory cytokines and prostaglandin E2 release

作者：Lim Jinwon; Lee Hyo Jung; Kim Bonglee; Choi Jeong Un; Shin Yoeok; Sohn Eun Jung; Kim Sung Hoon^*

来源：Chinese Science Bulletin, 2014, 59(25): 3127-3133.

DOI：10.1007/s11434-014-0360-0

• Hongbaekjeong
• NO
• Proinflammatory cytokine
• Analgesic
• PGE2

Though Hongbaekjeong (HBJ), a hebal mixture of three medicinal plants, has been traditionally used for arthritis and muscular pain, its scientific evidence still remains unclear. Thus, in the present study, analgesic and anti-inflammatory mechanism of HBJ was evaluated in vitro and in vivo. HBJ significantly reduced NO production and prostaglandin E2 (PGE2) release and also attenuated the expression of cyclooxygenase 2 (COX-2) in lipopolysaccharides (LPS) and interferon (IFN)-gamma treated RAW 264.7 cells. Furthermore, HBJ abrogated the production of proinflammatory cytokines such as interleukin (IL)1 beta, IL-6, IL-8 and monocyte chemoattractant protein-1(MCP-1) in LPS and IFN-gamma treated RAW 264.7 cells. In addition, HBJ significantly decreased the number of writhing syndrome induced by acetic acid, and also increased latency in hot-plate method and tail flick test in mice. Consistently, HBJ significantly reduced the edema volume in the hind paw of the rats with arthritis induced by Freund%26apos;s complete adjuvant (FCA) compared to untreated control. Collectively, our findings demonstrate the anti-inflammatory and analgesic potential of HBJ via inhibition of proinflammatory cytokines and PGE2 release for treatment of arthritis and muscular pain.

• 出版日期2014-9