Analysis of transition state stabilization by non-covalent interactions in organocatalysis: application of atomic and functional-group partitioned symmetry-adapted perturbation theory to the addition of organoboron reagents to fluoroketones

作者：Bakr Brandon W; Sherrill C David^*

来源：Physical Chemistry Chemical Physics, 2018, 20(27): 18241-18251.

DOI：10.1039/c8cp02029a

This work seeks to apply symmetry-adapted perturbation theory (SAPT) to the recent study of Hoveyda and co-workers [K. A. Lee et al., Nat. Chem. 2016, 8, 768] where an allyl addition to a ketone became enantioselective when the ketone was fluorinated. Through the application of atomic SAPT (A-SAPT) and functional-group SAPT (F-SAPT), the non-covalent interactions between specific atoms and functional groups in the transition states associated with the fluoroketone reactions can be quantified. Our A-SAPT analysis confirms that a H center dot center dot center dot F contact thought to enhance stereoselectivity shows a strong preference for one of the transition states leading to the experimentally observed product enantiomer. Other key atom-atom contacts invoked to rationalize relative transition state energies are also found to behave as expected based on chemical intuition and contact distances. On the other hand, hypothesized steric clashes between substrate phenyl or ortho-methyl phenyl groups and the catalyst are not supported by F-SAPT computations, and indeed, these are actually favorable pi-pi interactions.

• 出版日期2018-7-21