Analysis of Ecstasy Tablets Using Capillary Electrophoresis with Capacitively Coupled Contactless Conductivity Detection

作者：Porto Suely K S S; Nogueira Thiago^*; Blanes Lucas; Doble Philip; Sabino Bruno D; do Lago Claudimir L; Angnes Lucio

来源：Journal of Forensic Sciences, 2014, 59(6): 1622-1626.

DOI：10.1111/1556-4029.12573

• forensic science
• mCPP
• C4D
• 3
• 4-methylenedioxymethamphetamine
• meta-chlorophenylpiperazine
• MDMA
• capillary electrophoresis
• contactless conductivity detection

A method for the identification of 3,4-methylenedioxymethamphetamine (MDMA) and meta-chlorophenylpiperazine (mCPP) was developed employing capillary electrophoresis (CE) with capacitively coupled contactless conductivity detection ((CD)-D-4). Sample extraction, separation, and detection of Ecstasy tablets were performed in <10min without sample derivatization. The separation electrolyte was 20mm TAPS/Lithium, pH 8.7. Average minimal detectable amounts for MDMA and mCPP were 0.04mg/tablet, several orders of magnitude lower than the minimum amount encountered in a tablet. Seven different Ecstasy tablets seized in Rio de Janeiro, Brazil, were analyzed by CE-(CD)-D-4 and compared against routine gas chromatography-mass spectrometry (GC-MS). The CE method demonstrated sufficient selectivity to discriminate the two target drugs, MDMA and mCPP, from the other drugs present in seizures, namely amphepramone, fenproporex, caffeine, lidocaine, and cocaine. Separation was performed in <90sec. The advantages of using (CD)-D-4 instead of traditional CE-UV methods for in-field analysis are also discussed.

• 出版日期2014-11