Association of CYP3A7*1C and serum dehydroepiandrosterone sulfate levels in women with polycystic ovary syndrome

作者：Goodarzi Mark O; Xu Ning; Azziz Ricardo^*

来源：Journal of Clinical Endocrinology & Metabolism, 2008, 93(7): 2909-2912.

DOI：10.1210/jc.2008-0403

Context: Adrenal androgen excess is common in polycystic ovary syndrome ( PCOS) and appears to be heritable. CYP3A7 metabolizes dehydroepiandrosterone and its sulfate (DHEAS). A promoter variant, CYP3A7*1C, which results in persistent expression in adults, was associated with reduced DHEAS levels in a previous study, which led us to consider CYP3A7*1C as a modulator of adrenal androgen excess in patients with PCOS.
Objective: The objective was to replicate the association between CYP3A7*1C and reduced DHEAS levels in PCOS patients and assess its possible role in modulating testosterone levels.
Design: Women with and without PCOS were genotyped for CYP3A7*1C, and this variant was tested for association with DHEAS and total and free testosterone.
Setting: Subjects were recruited from the reproductive endocrinology clinic at the University of Alabama at Birmingham; controls were recruited from the surrounding community. Genotyping took place at Cedars-Sinai Medical Center ( Los Angeles, CA).
Participants: A total of 287 white women with PCOS and 187 controls were studied.
Main Measurements: CYP3A7*1C genotype, PCOS risk, and androgen levels were measured.
Results: PCOS subjects who carried the CYP3A7*1C variant had lower levels of serum DHEAS and total testosterone ( P = 0.0006 and 0.046, respectively). The variant was not associated with PCOS risk.
Conclusion: This study replicated priorworkof the association of CYP3A7*1C and decreased DHEAS in a different population of young PCOS women, providing further genetic evidence that CYP3A7 plays a potential role in modulation of DHEAS levels. Adult expression of CYP3A7 may modify the PCOS phenotype by ameliorating adrenal androgen excess.

• 出版日期2008-7-1
• 单位河北医科大学