Anesthesia and steep

作者：Tung A^*; Mendelson WB

来源：Sleep Medicine Reviews, 2004, 8(3): 213-225.

DOI：10.1016/j.smrv.2004.01.003

• anesthesia
• sleep deprivation
• sleep mechanism
• anesthetic mechanism
• sleep debt

Although both general anesthesia and naturally occurring steep depress consciousness, distinct physiological. differences exist between the two states. Recent lines of evidence have suggested that steep and anesthesia may be more similar than previously realized. Localization studies of brain nuclei involved in steep have indicated that such nuclei are important in anesthetic action. Additional observations that regional brain activity during anesthesia resembles that in the sleeping brain have raised the possibility that anesthesia may exert its effects by activating neuronal networks normally involved in steep.
In animals, behavioral interactions between steep and anesthesia appear to support these mechanistic similarities. Rat studies demonstrate that steep debt accrued during prolonged wakefulness dissipate during anesthesia. Moreover, anesthetic potency is subject both to circadian effects and to the degree of prior steep deprivation. Such interactions may partly explain anesthetic variability among patients.
Finally, steep and anesthesia interact physiologically. Endogenous neuromodulators known to regulate steep also alter anesthetic action, and anesthetics cause steep with direct administration into brain nuclei known to regulate steep. Together, these observations provide new research directions for understanding steep regulation and generation, and suggest the possibility of new clinical therapies both for patients with steep disturbances and for steep deprived patients receiving anesthesia.

• 出版日期2004-6