A Three-dimensional Dy-III-based Metal-organic Framework: Smart Drug Carrier and Anti-lung Cancer Activity

作者：Liu, Feng-Ji; Xu, Bing-Mei^*

来源：Zeitschrift fur Anorganische und Allgemeine Chemie, 2018, 644(15): 821-826.

DOI：10.1002/zaac.201800136

• Biphenyl-3,4 ',5-tricarboxylic acid
• Porous framework
• 5-Fu carrier
• Anticancer activity

A 3D lanthanide metal-organic framework (MOF) with the formula [Dy-2(L)(2)(H2O)(2)](n) (1) (H3L = biphenyl-3,4,5-tricarboxylic acid) was synthesized under solvothermal conditions and structurally characterized by elemental analysis, powder X-ray diffraction analysis, infrared spectroscopy, and single-crystal X-ray diffraction analysis. Compound 1 features a 3D porous framework based on 1D rod-shaped Dy-III-carboxylate chains. The efficient encapsulation and controllable release of an anticancer drug (5-Fu) make it a promising drug delivery host. Furthermore, the GCMC simulation was used to probe the drug-framework interaction at the atomic lever. The in vitro anti-lung cancer activity of 1 and 5-Fu loaded 1a were also evaluated using MTT assay.

• 出版日期2018-8-16
• 单位潍坊市人民医院