Determination of vascular permeability coefficients under slow luminal filling

作者：Truslow James G; Tien Joe^*

来源：Microvascular Research, 2013, 90: 117-120.

DOI：10.1016/j.mvr.2013.07.003

This Communication describes a method to obtain the permeability product (permeability coefficient normalized by vascular dimensions) from time-lapse intensity data for which the introduction of labeled solute into the vasculature does not occur at a sharply defined time. This method has an error of similar to 10% across a wide range of filling times and noise levels, and is particularly well-suited for situations in which the permeability coefficient is greater than 10(-6) cm/s. We show that it is applicable whether the increase in vascular solute concentration is sustained or transient.

• 出版日期2013-11