Applications of extractive electrospray ionization (EESI) in analytical chemistry

作者：Koyanagi Gregory K; Blagojevic Voislav; Bohme Diethard K^*

来源：International Journal of Mass Spectrometry, 2015, 379: 146-150.

DOI：10.1016/j.ijms.2015.01.011

• Extractive electrospray ionization
• Salt-rich solutions
• Oxidizable analytes
• TEMPO

Effects occurring in quantitative analyses from salt-rich solutions and of easily oxidizable analytes were studied using an Extractive Electrospray Ionization (EESI) source. A low detection limit of 100 pM was achieved for the drug propanolol in the presence of 25 mM TRIS salt. The oxidation of TEMPO, a stable radical, was found to be dependent on the solvent flows and could be related to a competition between two different ionization mechanisms. The addition of a source air heater was found to improve ion desolvation and increase EESI signal intensities to from 2-5% to 30-90% of the ESI intensity. These results are very encouraging for the further development of the EESI source.

• 出版日期2015-3-15