A Severe Form of Churg-Strauss Syndrome Complicated with Acute Cardiac Failure and Rapidly Progressive Peripheral Neuropathy-A Possible Effect of Intravenous Immunoglobulin Therapy

作者：Kobayashi Daisuke^*; Wada Yoko; Takata Takuma; Koya Toshiyuki; Murakami Shuichi; Ozawa Takuya; Aizawa Yoshifusa; Kuroda Takeshi; Nakano Masaaki; Narita Ichiei

来源：Internal Medicine, 2011, 50(8): 925-929.

DOI：10.2169/internalmedicine.50.4648

• Churg-Strauss syndrome (CSS)
• intravenous administration of a high-dose human immunoglobulin (IVIg)
• acute cardiac failure
• peripheral neuropathy

We report a case of Churg-Strauss syndrome (CSS) complicated by severe cardiac failure and peripheral neuropathy. Two courses of methylprednisolone pulse therapy were unable to control the disease activity. Repeated intravenous administration of high-dose human immunoglobulin (IVIg) was added together with intravenous cyclophosphamide pulse therapy (IVCY), and the patient's cardiac function and neurological symptoms were gradually ameliorated without any adverse event. Although glucocorticoid and cyclophosphamide comprise the standard therapy for patients with CSS, a number of patients with severe complications appear to be resistant to such conventional treatment. IVIg is thought to be an effective therapeutic option for such patients.

• 出版日期2011