High urine IP-10 levels associate with chronic HCV infection

作者：Petrone Linda; Chiacchio Teresa; Vanini Valentina; Petruccioli Elisa; Cuzzi Gilda; Di Giacomo Cristina; Pucci Luigia; Montalbano Marzia; Lionetti Raffaella; Testa Angela; Lapa Daniele; Navarra Assunta; Visco Comandini Ubaldo; Goletti Delia^*

来源：Journal of Infection, 2014, 68(6): 591-600.

DOI：10.1016/j.jinf.2014.02.008

• IP-10
• HCV
• Biomarkers
• Urine
• Serum
• SVR
• Cured-HCV subjects
• pnALT

Objectives: Independent of IL-28B polymorphisms, blood IP-10 is a promising biomarker for predicting therapy response in chronic HCV infection. Urine IP-10 has been proposed as a biomarker in tuberculosis, but to date, no urine biomarkers for HCV infection have been evaluated. In this cross-sectional study, we assessed whether IP-10 is detectable in the urine of chronically HCV-infected patients, and if so, whether urine IP-10 correlates with serum IP-10 and HCV-specific clinical parameters.
Methods: IP-10 was measured by ELISA in serum and urine concomitantly taken from 38 HCVviremic patients, 10 cured-HCV subjects and 11 healthy donors enrolled as controls.
Results: The urine of HCV-viremic patients showed measurable amounts of IP-10, although significantly lower than in serum (p < 0.0001). Urine IP-10 was normalized with creatinuria levels and we found that the urine IP-10/creatinuria ratio was significantly higher in HCVviremic patients than in cured-HCV subjects (p = 0.002) and healthy donors (p = 0.008), and that it significantly correlated with transaminases (p = 0.01), although the correlation was low. Similarly, the serum IP-10 level significantly associated with HCV-viremic patients (p < 0.0001) and correlated with transaminases (p < 0.0001).
Conclusions: For the first time to our knowledge, we show that IP-10 is detected and increased in the urine of HCV-viremic patients compared to healthy donors and cured-HCV subjects.

• 出版日期2014-6