Artosimmin- A Potential Anti-Cancer Lead Compound from Artocarpus odoratissimus

作者：Ee Gwendoline C L^*; Teo Siow H; Rahmani Mawardi; Lim Chan K; Lim Yang M; Bong Choon F J

来源：Letters in Organic Chemistry, 2010, 7(3): 240-244.

• Artocarpus odoratissimus
• moraceae
• pyranoflavone
• triterpenoid
• cytotoxicity
• antioxidant

Our recent study on Artocarpus odoratissimus (Moraceae) has resulted in the purification of a new prenylated pyranoflavone derivative artosimmin (1) and traxateryl acetate (2). Details of structural elucidations associated with 1 and 2 are reported by combining 1D, 2D NMR and mass spectrometric methods. Compound 2 is obtained for the first time from this species. Furthermore, the biological assay results exhibited compound 1 to be significantly cytotoxic against cancer cell lines (HL-60 & MCF-7) and also possessed antioxidant properties toward 1,1-diphenyl-2-picrylhydrazyl radical (DPPH).

• 出版日期2010-4