Universal Area Distributions in the Monolayers of Confluent Mammalian Cells

作者:Wilk Gary; Iwasa Masatomo; Fuller Patrick E; Kandere Grzybowska Kristiana; Grzybowski Bartosz A*
来源:Physical Review Letters, 2014, 112(13): 138104.
DOI:10.1103/PhysRevLett.112.138104

摘要

When mammalian cells form confluent monolayers completely filling a plane, these apparently random "tilings" show regularity in the statistics of cell areas for various types of epithelial and endothelial cells. The observed distributions are reproduced by a model which accounts for cell growth and division, with the latter treated stochastically both in terms of the sizes of the dividing cells as well as the sizes of the "newborn" ones-remarkably, the modeled and experimental distributions fit well when all free parameters are estimated directly from experiments.