Advance in The Relationship Between Sterol Regulatory Element-binding Proteins and Inflammation

作者：Pan Yan-Jun; Wang Yan; Xu Jian-Qiang; Wu Jian-Feng; Yu Si-Yang; Zeng Gao-Feng^*; Zhao Guo-Jun^*

来源：Progress in Biochemistry and Biophysics, 2016, 43(12): 1146-1153.

DOI：10.16476/j.pibb.2016.0228

• sterol regulatory element-binding protein
• inflammation
• lipid metabolism

Sterol regulatory element-binding proteins (SREBPs) are important nuclear transcription factors, which play critical role in maintaining the balance of lipid metabolism via activating the expression of genes associated with the synthesis and uptake of cholesterol, fatty acids and triglycerides (TG). Recently, it has been shown that SREBPs have a close relationship with inflammation. SREBPs can promote the occurrence and development of inflammation. On the other hand, the inflammation can affect the expression of SREBPs, and thereby lead to dyslipidemia. Further research on the relationship between SREBPs and inflammation may provide novel direction for the prevention and treatment of diseases induced by inflammation and dyslipidemia.

• 出版日期2016-12
• 单位中南大学; 桂林医学院; 南华大学