摘要
A new resveratrol dimer, ( )-vitisinol E (1) which demonstrated inhibitory activity on BACE-1 (beta-site APP-cleaving enzyme 1) in vitro, was isolated from the stembark extract of Vitis vinifera (Vitaceae) together with four known resveratrol oligomers, ( )-epsilon-viniferin (2), ( )-ampelopsin A (3), ( )-vitisin A (4) and (-)-vitisin B (5). The chemical structure of I was established by MR spectroscopic analyses, including HMBC. All isolated resveratrol derivatives (1-5) demonstrated significant inhibition on baculovirus-expressed BACE-1 in a dose-dependent manner, which was assessed with the FRET assay using Rh-EVNLDAEFK as a substrate in vitro.
- 出版日期2009-4