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摘要
Ethyl 1,2-dihydro-1,6-dimethyl/6-methyl-2-oxopyrimidine-5-carboxylates react with C-nucleophiles as well as the anion of the enantiopure chiral auxiliary (1R,2S,5R)-(-)-methyl (S)p-toluenesulfinate to afford 4-substituted and enantiopure congeners of medicinally potent Biginelli dihydropyrimidinones. The calcium channel blocking activity of some of the compounds was evaluated and compared with nifedipine for their ability to relax a membrane depolarization-induced contraction.
- 出版日期2009-7
