Antigen-specific T-cell induction by vaccination with a recombinant Sendai virus vector even in the presence of vector-specific neutralizing antibodies in rhesus macaques

作者：Moriya Chikaya; Horiba Satoshi; Inoue Makoto; Iida Akihiro; Hara Hiroto; Shu Tsugumine; Hasegawa Mamoru; Matano Tetsuro^*

来源：Biochemical and Biophysical Research Communications, 2008, 371(4): 850-854.

DOI：10.1016/j.bbrc.2008.04.156

• Sendai virus vector
• AIDS vaccine
• SIV
• neutralizing antibody
• CTL

Recombinant viral vectors are promising vaccine tools for eliciting potent cellular immune responses against immunodeficiency virus infection, but pre-existing anti-vector antibodies can be an obstacle to their clinical use in humans. We have previously vaccinated rhesus macaques with a recombinant Sendai virus (SeV) vector twice at an interval of more than 1 year and have shown efficient antigen-specific T-cell induction by the second as well as the first vaccination. Here, we have established the method for measurement of SeV-specific neutralizing titers and have found efficient SeV-specific neutralizing antibody responses just before the second SeV vaccination in these macaques. This suggests the feasibility of inducing antigen-specific T-cell responses by SeV vaccination even in the host with pre-existing anti-SeV neutralizing antibodies.

• 出版日期2008-7-11
• 单位河北医科大学