A Novel Tandem Sequence to Pyrrole Syntheses by 5-endo-dig Cyclization of 1,3-Enynes with Amines

作者:Bharathiraja Ganesan; Sakthivel Sekarpandi; Sengoden Mani; Punniyamurthy Tharmalingam*
来源:Organic Letters, 2013, 15(19): 4996-4999.
DOI:10.1021/ol402305b

摘要

The synthesis of pentasubstituted pyrroles has been described using molecular iodine from 1,3-enynes and amines via a sequential tandem aza-Michael addition, iodocyclization, and oxidative aromatization. The protocol is simple and efficient to afford the target products at ambient conditions.

  • 出版日期2013-10-4