Association of vitamin D receptor gene polymorphisms with serum 25(OH)D levels and metabolic syndrome in Thai population

作者：Sangkaew Boonnisa; Nuinoon Manit; Jeenduang Nutjaree^*

来源：Gene, 2018, 659: 59-66.

DOI：10.1016/j.gene.2018.03.047

• VDR
• Polymorphism
• Metabolic syndrome
• Serum 25(OH)D

Metabolic syndrome (MetS) increases the risk of developing cardiovascular disease (CVD) and type 2 diabetes mellitus (T2DM). The vitamin D receptor gene (VDR) polymorphisms have been found associated with MetS and serum 25(OH)D levels but these associations remain controversial. The aim of this study was to investigate the relationship between the VDR polymorphisms and MetS, metabolic components, and serum 25(OH)D levels within the Thai population. A case control study included 237 participants with MetS according to the MetS diagnostic criteria of NCEP ATPIII and 376 controls. Anthropometric data, blood pressure, lipid profiles, serum 25 (OH)D, and fasting blood glucose were measured. VDR Fokl, Bsml, Taql, and Cdx2 polymorphisms were genotyped by using PCR-HRM. There were no significant differences in the frequencies of VDR genotypes and alleles between MetS and the control groups. VDR Tagl TT, and Bsml BB + Bb genotypes were associated with lower 25(OH)D levels (p < 0.05) in comparison to Taql Tt, and Bsml bb genotypes in the MetS group, respectively. In addition, the VDR Cdx2 GG genotype was associated with higher WC compared with the AG genotype in all subjects (p < 0.05). Logistic regression analysis revealed that BB + Bb genotypes of the VDR Bsml had significantly increased the odds ratio (OR) of hypertriglyceridemia when compared with the bb genotype (OR 1.87; 95% CI 1.10-3.19, p = 0.022). In conclusion, VDR Bsml variant was associated with hypertriglyceridemia and may be predisposed to developing MetS. VDR Tag' and Bsml polymorphisms seems to influence serum 25(OH)D levels in MetS subjects, while Cdx2 polymorphism may influence WC in all subjects.

• 出版日期2018-6-15