Association analysis between 8-oxoguanine DNA glycosylase genetic variants and endometrial cancer susceptibility in Chinese Han population

作者：Wang, Lijuan; Li, Jing; Lu, Huaiwu; Zhou, Hui; Xie, Lingling; Wu, Miaofang; Lin, Zhongqiu^*

来源：Journal of Pharmacy and Pharmacology, 2015, 67(4): 559-564.

DOI：10.1111/jphp.12348

• cancer susceptibility
• endometrial cancer
• genetic variants
• hOGG1 gene
• molecular markers

ObjectivesNumerous epidemiologic studies demonstrate that 8-oxoguanine DNA glycosylase gene (hOGG1) is an important candidate gene for the development of endometrial cancer (EC). The objective of this study is to evaluate the potential association between hOGG1 genetic variants and the susceptibility to EC. @@@ MethodsIn total, 218 EC patients and 243 cancer-free controls were recruited in this study. @@@ Key findingsOur data indicate that the hOGG1 c.269C>A and c.828A>G genetic variants are statistically associated with the increased susceptibility to EC (for c.269C>A, AA vs CC: odds ratio (OR)=2.14, 95% confidence interval (CI), 1.21 to 3.78, P=0.008; A vs C: OR=1.43, 95% CI, 1.09 to 1.88, P=0.010; for c.828A>G, GG vs AA: OR=2.31, 95% CI, 1.24 to 4.30, P=0.008; G vs A: OR=1.35, 95% CI, 1.03 to 1.78, P=0.032). The A allele and AA genotype of c.269C>A and G allele and GG genotype of c.828A>G genetic variants could contribute to the susceptibility to EC. @@@ ConclusionTaken together, our findings suggest that the hOGG1 c.269C>A and c.828A>G genetic variants are significantly associated with EC susceptibility in Chinese Han populations and might be used as molecular markers for assessing the risk of EC.

• 出版日期2015-4
• 单位中山大学