Dental sedation for patients with intellectual disability: a prospective study of manual control versus Bispectral Index-guided target-controlled infusion of propofol

作者：Sakaguchi Mai; Higuchi Hitoshi^*; Maeda Shigeru; Miyawaki Takuya

来源：Journal of Clinical Anesthesia, 2011, 23(8): 636-642.

DOI：10.1016/j.jclinane.2011.04.008

• Bispectral index
• Dental treatments
• Intellectual disability
• Intravenous sedation
• Target-controlled infusion

Study Objective: To investigate the use of propofol sedation using Bispectral Index (BIS)-guided target-controlled infusion (TCI) in dental patients with intellectual disability.
Design: Single-center, prospective, randomized clinical trial.
Setting: Academic outpatient clinic.
Subjects: 40 ASA physical status 1 and 2 patients with intellectual disability.
Interventions: Patients were randomized to two groups. The manual control (MC) group (n = 20) had sedation by manually controlled infusion of propofol without a BIS index monitor. The BIS-TCI group (n = 20) had sedation by BIS-guided TCI of propofol.
Measurements: The required dose of propofol, recovery time for the eyelash reflex, and spontaneous eye opening times were recorded.
Main Results: BIS-TCI significantly reduced the dose of propofol and shortened the recovery times for eyelash reflex and spontaneous eye opening.
Conclusion: Propofol sedation using BIS-guided TCI is a useful and safe method in the management of patients with intellectual disability.

• 出版日期2011-12