A facile synthesis of novel 3-(aryl/alkyl-2-ylmethyl)-2-thioxothiazolidin-4-ones using microwave heating

作者：Kamila Sukanta; Ankati Haribabu; Harry Emily; Biehl Edward R^*

来源：Tetrahedron Letters, 2012, 53(17): 2195-2198.

DOI：10.1016/j.tetlet.2012.02.064

• Microwave irradiation
• 2-Thioxothiazolidin-4-onse
• 2-(1H-Indol-3-yl)-2-oxoacetaldehydes
• Acid chlorides
• Rhodanines

(Z)-5-(2-(1H-Indol-3-yl)-2-oxoethylidene)-3-(aryl/alkyl-2-ylmethyl)-2-thioxothiazolidin-4-ones (7a-w) have been synthesized by the Knoevenagel condensation reaction of 3-(aryl/alkyl-2-ylmethyl)-2-thioxothiazolidin-4-ones (3a-d) with suitably substituted 2-(1H-indol-3-yl)2-oxoacetaldehydes (6a-g) under microwave conditions. The thioxothiazolidin-4-ones were prepared from the corresponding aryl/alkyl amines (1a-d) and di-(carboxymethyl)-trithiocarbonyl (2). The aldehydes (6a-g) were synthesized from the corresponding acid chlorides (5a-g) using HsnBu(3).

• 出版日期2012-4-25