Toll-like Receptor 3 L412F Polymorphisms in Infants With Bronchiolitis and Postbronchiolitis Wheezing

作者：Nuolivirta Kirsi^*; He Qiushui; Vuononvirta Juho; Koponen Petri; Helminen Merja; Korppi Matti

来源：Pediatric Infectious Disease Journal, 2012, 31(9): 920-923.

DOI：10.1097/INF.0b013e31825aff25

• bronchiolitis
• infant
• gene
• Toll-like receptor 3
• wheezing

Background: Innate immunity receptors play a critical role in host defense. In addition, the expression of Toll-like receptors (TLRs) has been connected to allergy and asthma. %26lt;br%26gt;Aims: To evaluate the association between the TLR3 L412F polymorphism and viral findings, clinical characteristics and subsequent wheezing in young infants with bronchiolitis. %26lt;br%26gt;Methods: In all, 129 full-term infants hospitalized for bronchiolitis at age %26lt;6 months have been followed-up until the mean age of 1.5 years. Genotyping of the TLR3 L412F gene mutation was made by pyrosequencing. %26lt;br%26gt;Results: TLR3 L412F gene polymorphism including the minor allele T was overrepresented (52%) in infants hospitalized with bronchiolitis. The presence of the major allele C as homozygous was associated with repeated postbronchiolitis wheezing (7.06, 95% confidence interval 2.30-21.66). %26lt;br%26gt;Conclusion: Preliminary evidence was found that TLR3 L412F gene polymorphism may be associated with bronchiolitis leading to hospitalization and postbronchiolitis wheezing.

• 出版日期2012-9