Neopetrosiquinones A and B, sesquiterpene benzoquinones isolated from the deep-water sponge Neopetrosia cf. proxima

作者：Winder, Priscilla L; Baker, Heather L; Linley, Patricia; Guzman, Esther A; Pomponi, Shirley A; Cristina Diaz, M; Reed, John K; Wright, Amy E^*

来源：Bioorganic & Medicinal Chemistry, 2011, 19(22): 6599-6603.

DOI：10.1016/j.bmc.2011.09.026

• Neopetrosiquinone
• Petrosia cf. proxima
• Deep-water
• Sponge
• Sesquiterpene quinone
• Marine natural products
• Cytotoxic
• beta-Catenin
• Tcf-4

Two new marine-derived sesquiterpene benzoquinones which we designate as neopetrosiquinones A (1) and B (2), have been isolated from a deep-water sponge of the family Petrosiidae. The structures were elucidated on the basis of their spectroscopic data. Compounds 1 and 2 inhibit the in vitro proliferation of the DLD-1 human colorectal adenocarcinoma cell line with IC(50) values of 3.7 and 9.8 mu M, respectively, and the PANC-1 human pancreatic carcinoma cell line with IC(50) values of 6.1 and 13.8 mu M, respectively. Neopetrosiquinone A (1) also inhibited the in vitro proliferation of the AsPC-1 human pancreatic carcinoma cell line with an IC(50) value of 6.1 mu M. The compounds are structurally related to alisiaquinone A, cyclozonarone, and xestoquinone.

• 出版日期2011-11-15