Desmiflavasides A and B: Two new bioactive pregnane glycosides from the sap of Desmidorchis flava

作者：Raees Muhammad Adil; Hussain Hidayat^*; Rehman Najeeb Ur; Khan Husain Yar; Abbas Ghulam; Al Rawahi Ahmed; Elyassi Ali; Al Amri Issa Sulaiman; Green Ivan R; Al Broumi Mohammed Abdullah; Mahmood Talat; Al Harrasi Ahmed

来源：Phytochemistry Letters, 2015, 12: 153-157.

DOI：10.1016/j.phytol.2015.03.013

• Desmidorchis flava
• NMR
• Pregnane glycoside
• Anticancer activity

The sap from the succulent, Desmidorchis flava (N.E.Br) Meve & Liede (Apocyanaceae), provided two new pregnane glycosides named desmiflavasides A (1) and B (2) whose structures were established from 1D and 2D NMR spectroscopic techniques and mass spectromentry (ESIMS) measurements. Desmiflavaside B (2) was tested for anticancer activity and induced a 27.4% and 33.1% growth inhibition of the breast cancer cell line (MDA MB231) at a concentration of 75 mu g/ml and 100 mu g/ml, respectively. Desmiflavasides A (1) and B (2) were additionally evaluated for: DPPH antioxidant activity, urease enzyme inhibition as well as for xanthine oxidase enzyme, alpha-glucosidase enzyme and acetylcholinesterase inhibition activities. They displayed weak antioxidant and urease enzyme inhibition activities with 15% inhibition.

• 出版日期2015-6