A novel multiple soaking temperature (MST) method to prepare polylactic acid foams with bi-modal open-pore structure and their potential in tissue engineering applications

作者：Huang Jiang Nan; Jing Xin; Geng Li Hong; Chen Bin Yi; Mi Hao Yang; Peng Xiang Fang^*

来源：Journal of Supercritical Fluids, 2015, 103: 28-37.

DOI：10.1016/j.supflu.2015.04.019

• Batch foaming
• Bi-modal open-pore structure
• Multiple soaking temperature
• Polylactic acid
• Biocompatibility

Bi-modal pore structures were obtained by stepwise depressurization in batch foaming method. In this study, a novel method was developed to produce polylactic acid (PLA) foam with bi-modal pore structure by using multiple soaking temperature (MST) method based on one-step pressure release. The effects of soaking time and temperatures on the formation of bi-modal pore structure were investigated in detail. The formation of macro pores was attributed to the synergistic effect of the supercritical carbon dioxide (SC-CO2) aggregation and the depressurization process. Moreover, bi-modal open-pore structures could be obtained at certain processing conditions. The PLA foams achieved porosity and open pore content as high as 87.9% and 82.4%, with average macro and micro pore size of 150 mu m and 8 mu m, respectively. The biocompatibility of the PLA open-pore foams was verified by 3T3 fibroblast cell culture.

• 出版日期2015-8
• 单位华南理工大学