科研之友
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摘要
Introduction: A radiocephalic arteriovenous fistula (AVF) is the best choice for achieving vascular access (VA) for hemodialysis, but this AVF has high rates of early failure due to juxta-anastomotic stenosis, making it impossible to use for dialysis. Low hemodynamic shear stress contributes to the pathophysiology of VA failure due to secondary thrombosis, stenosis, and re-occlusion after percutaneous intervention. Methods: We used a computational fluid dynamics (CFDs) approach to evaluate the shear stress distribution and minimize its effects under various conditions including changes in the anastomosis angle. A three-dimensional computational domain was designed for arteriovenous end-to-side anastomosis based on anastomosis angles of 45 degrees, 90 degrees and including 135 degrees angle of an obtuse anastomosis using three-dimensional design software. COMSOL Multiphysics (R) simulation software was used to identify the hemodynamic factors influencing wall shear stress at the anastomosis site using a low Reynolds number k-epsilon turbulence model that included non-Newtonian blood flow characteristics, the complete cardiac pulse cycle, and distention of blood vessels. In preliminary clinical study, all 201 patients who received a radiocephalic wrist AVF from January 2009 to February 2014 were divided into classic and obtuse angle groups. Results: The CFD results showed that the largest anastomosis angle (135 degrees) resulted in lower shear stress, which would help reduce AVF failures. This obtuse angle was preferred, as it minimized the development of anastomotic stenosis and tended to favor primary and primary-assisted patency in clinical study. Conclusions: An obtuse radiocephalic wrist AVF shows more favorable patency compared to a classic radiocephalic AVF. Surgeons establishing a radiocephalic wrist AVF would be better to consider an AVF with an obtuse anastomosis.
- 出版日期2016-12
