科研之友
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摘要
Therapeutic hypothermia has been the most effective therapy to treat serious cardiovascular and cerebrovascular diseases. Among them, intravascular cooling is identified as a most efficient approach to induce brain hypothermia. However until now, some key parameters and temperature management method for intravascular cooling are still not well addressed because of the complexity of human thermoregulation mechanism. Aiming at predicting temperature variation of tissues and organs in a more accurate way during therapeutic hypothermia, this study is dedicated to integrate the blood flow model in the circle of Willis together with the compartmental model for characterizing the heat and blood transport throughout the whole human body. According to the theoretical evaluation, the new model could well simulate the temperature response of the whole human body especially the brain under various cooling. Effects of different intervention site and cooling power to the hypothermia performance are discussed, which shows that carotid artery intervention is a more suitable therapeutic hypothermia method in comparison with femoral artery or femoral vein intervention. These results could help design controlling software for intravascular therapeutic hypothermia device in the near future.
- 出版日期2011-12
- 单位中国科学院理化技术研究所
