Antisolvent Crystallization of Polymorphs of L-Histidine

作者：Punmalee Neeranuch; Wantha Lek^*; Flood Adrian E

来源：Chemical Engineering & Technology, 2018, 41(6): 1132-1138.

DOI：10.1002/ceat.201700676

• Antisolvent crystallization
• L-Histidine
• Induction time
• Polymorphs
• Supersaturation

Antisolvent crystallization is the most common method to study solvent effects on polymorphic crystallization. L-Histidine (L-his) served as a model substance. Acetonitrile, acetone, and methanol were selected as antisolvents, with water as solvent. The formation of L-his polymorphs in antisolvent crystallization as a function of supersaturation, antisolvent volume fraction, and temperature was studied. The solubility of polymorphA of L-his decreased with increasing volume fraction of antisolvent and increased with higher temperature. The metastable polymorphB of L-his was obtained at higher antisolvent volume fraction and supersaturation. At lower antisolvent volume fraction and supersaturation, a mixture of polymorphsA and B was detected.

• 出版日期2018-6