Application of Volumetric Modulated Arc Therapy and Simultaneous Integrated Boost Techniques to Prepare "Safe Margin" in the Rabbit VX2 Limb Tumor Model

作者：Wang, Chong-Wen; Zhou, Yang; Bai, Jing-Ping^*; Liu, Hao; Liu, Yan; Shi, Guang-Li; Ding, Jiao-Jiao; Ma, Dong-Hui; Li, Wen-Ting; Xie, Peng-Ming; Yan, Yue

来源：MEDICAL SCIENCE MONITOR, 2015, 21: 2397-2405.

DOI：10.12659/msm.894909

• Rabbits
• Radiotherapy
• Intensity-Modulated
• Diffusion Magnetic Resonance Imaging
• Ultrasonography, Doppler
• Histological Techniques

Background: In this study, we aimed to establish the rabbit VX2 limb tumor model, and then prepare a "necrotic zone" as a safe margin by volumetric modulated arc therapy and simultaneous integrated boost (VMAT-SIB) technique applied in the areas where the tumor is located adjacent to the bone (GTV(boost) area).
Material/Methods: Rabbits in the control group (n=10) were not treated, while those in the test group (n=10) were treated with the SIB schedule delivering a dose of 40Gy, 35Gy, 30Gy, and 25Gy to the GTV(boost), GTV (gross tumor volume), CTV (clinical target volume), and PTV (planning target volume) in 10 fractions. Magnetic resonance diffusion-weighted imaging (MRDWI), 3-dimensional power Doppler angiography (3D-PDA), and histological changes were observed after radiotherapy.
Results: After radiotherapy, the two groups showed a significant difference in the GTV(boost) area. In the test group, the tumor necrosis showed a significantly low signal in DWI and high signal in apparent diffusion coefficient (ADC) maps. The 3D-PDA observation showed that tumor vascular structures decreased significantly. Histological analysis demonstrated that a necrotic zone could be generated in the GTV(boost) area, and microscopic examination observed cell necrosis and fibroplasia.
Conclusions: This studies demonstrated the feasibility of using VMAT-SIB technique in the rabbit VX2 limb tumor model. The formation of a necrotic zone can be effectively defined as safe margin in the GTV(boost) area. showing potential clinical applicability.

• 出版日期2015-8-15
• 单位新疆医科大学