A method for optical imaging and monitoring of the excretion of fluorescent nanocomposites from the body using artificial neural networks

作者：Sarmanova Olga E; Burikov Sergey A; Dolenko Sergey A; Isaev Igor V; Laptinskiy kirill A; Prabhakar Neeraj; Sen Karaman Didem; Rosenholm Jessica M; Shenderova Olga A; Dolenko Tatiana A^*

来源：Nanomedicine: Nanotechnology, Biology and Medicine , 2018, 14(4): 1371-1380.

DOI：10.1016/j.nano.2018.03.009

• Carbon nanocomposite
• Fluorescent imaging probe
• Fluorescent spectroscopy
• Artificial neural networks

In this study, a new approach to the implementation of optical imaging of fluorescent nanoparticles in a biological medium using artificial neural networks is proposed. The studies were carried out using new synthesized nanocomposites-nanometer graphene oxides, covered by the poly(ethylene imine)-poly(ethylene glycol) copolymer and by the folic acid. We present an example of a successful solution of the problem of monitoring the removal of nanocomposites based on nGO and their components with urine using fluorescent spectroscopy and artificial neural networks. However, the proposed method is applicable for optical imaging of any fluorescent nanoparticles used as theranostic agents in biological tissue.

• 出版日期2018-6