科研之友
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Background: Adiponectin is the most abundant adipokine shown to have insulin-sensitizing, antiatherogenic, and anti-inflammatory properties. Adiponectin level, unlike that of other adipocytokines, is decreased in obesity and type 2 diabetes and increased after weight reduction. Recent studies suggest that adiponectin plays an important role in linking obesity with different cardiometabolic risk factors. Neverseless, a few studies have investigated this relationship in obese children. Racial differences in adiponectin level were observed, but little work has been done to determine if plasma adiponectin concentrations differ as a result of ethnicity. In few studies in African American, lack of a relationship between plasma adiponectin, obesity, and insulin sensitivity were reported despite the prevalence of obesity, diabetes, and insulin resistance in this population. However todate, there are no reports examining similar relationship of adiponectin and different cardiometabolic variables in African Egyptian. Aim of the study: To investigate the relationship between adiponectin, and different cardiometabolic and anthropometric variables in African Egyptian adolescence, in a trial to further explore, whether this relation in the African race differ from other ethnic population. Subjects and methods: A cross-sectional survey was conducted by the National Research Centre, Egypt. The survey comprised 3708 adolescents (48% boys and 52% girls), aged from 12 to 18 years (+/- 6 months). Of the total sample, only 340 students (9.2%) were obese (8.1% boys and 10.2% girls); with mean age 14.36 +/- 1.66 years. The included 180 obese students; who accepted to share in the laboratory tests; underwent complete physical examination, including different anthropometric measures (Height, weight, body mass index, waist circumference, hip circumference and waist/hip ratio). Blood pressure was also measured. Fasting venous blood samples were collected to detect fasting blood glucose, fasting serum insulin and adiponectin levels. Meanwhile insulin resistance was calculated. Results: Serum adiponectin level was low compared to the kit reference range. It did not show any significant correlations with the studied anthropometric parameters; both the systolic and diastolic blood pressure, the fasting plasma glucose, insulin level and insulin resistance (HOMA-IR). Conclusion: Although the present study, proved that serum adiponectin level was low in the studied African Egyptian obese adolescence, but it could not prove a direct link between adiponectin and the studied anthropometric measures, and cardiometabolic variables. This may provide additional support for the notion that what applies to other ethnic populations might not apply to the African population. [Nayera E. Hassan, Sahar A. El-Masry, Tarek S. Ibrahim, Walaa A. Fouad, Wagdi M. Hanna, and Mehrevan M. Abd El-moniem. Adiponectin in African Egyptian Obese Adolescents. Life Science Journal. 2011;8(2):275-280] (ISSN:1097-8135). http://www.lifesciencesite.com.
- 出版日期2011
